Sandro Botticelli (1445-1510) painted a number of portraits, although not nearly as many as have been attributed to him.
There are a number of idealized portrait-like paintings of women which probably do not represent a specific person (several closely resemble the Venus in his Venus and Mars).
Traditional gossip links these to the famous beauty Simonetta Vespucci, who died aged twenty-two in 1476, but this seems unlikely.
These figures represent a secular link to his Madonnas.