María Isabel of Braganza was born in Lisbon on 19 May 1797, daughter of John VI of Portugal and Carlota Joaquina of Spain.
She became queen of Spain when she married her uncle, Ferdinand VII, on 28 September 1816 and became his second wife.
She died during childbirth in Aranjuez on 26 December 1818.
It must be noted that this is a posthumous portrait.
The artist was the son of Vicente López and his most faithful disciple.
Bernardo López Piquer (1801-1874) | Maria Isabel of Portugal in front of the Prado in 1829 | Museo del Prado